Jason Pugh, PhD

Associate Professor

The goal of the Pugh lab is to understand how neurons transmit and store information through synaptic connections. We are investigating both the basic mechanisms of synaptic transmission and synaptic plasticity and how specific diseases alter synapse funciton. Specifically, we are interested in understanding how endocannabinoid signaling regulates synaptic plasticity and behavior learning in the cerebellar circuit. We are also interested in how genetic diseases, such as Duchenne muscular dystrophy, affect synapse formation, structure, function, and plasticity. To address these questions, we use a combination of patch-clamp electrophysiology, two-photon calcium imaging, immunofluorescent labeling, and novel genetic models of neurodevelopmental diseases.

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